Part 1

Lipids, Lipoproteins and Cardiovascular Disease - Diagnosis of cardiovascular disease.

The following Questions are mandatory: (500 words each with diagrams where necessary)

Question 1. Describe the development of atherosclerosis.

Question 2. What use are triglyceride measurements in Chronic Heart Disease (CHD) and discuss its association with other disease states, particularly pancreatitis?

Question 3. List some of the risk factors for Cardio Vascular Disease (CVD).

Question 4. Discuss treatment of primary hyperlipidaemia by referencing NICE guidelines. What are the causes of primary and secondary hyperlipidaemia?

Question 5. Discuss the principles and limitations of the analytical methods and sample requirements for cholesterol, Triglyceride, HDL and LDL Cholesterol.

Answer any 4 of the following questions:(500 words each with diagrams where necessary)

Question 1. Discuss the effects of gender, age, exercise, obesity, alcohol and extraneous oestrogens on lipoproteins.

Question 2. Describe the role of laboratory tests in aiding the diagnosis, treatment and monitoring of Cardiovascular Diseases

Question 3. What other markers of CHD have been suggested?

Question 4. Describe the test principles of Roche LDL assay.

Question 5. Discuss effect of interference in Roche LDL assay

Question 6. Describe CHD and triglyceride measurements and association with pancreatitis and other disease states.

Part 2

Reflective Log (500 words)

What have you learnt?
How can you use what you have learnt?
How is this relevant/helpful to service users?Example patients, Clinicians and healthcare providers

Summarise the laboratory role in the previous section(s):
Your understanding of how the laboratory operates within this section?

GUILDLINE
SCOPE: YOUR ANSWERS MUST COVER THIS AREAS FOR SECTION 1

KNOWLEDGE

The candidate is expected to be able to demonstrate knowledge and understanding of the following:

Question 1. National or international guidelines in determining risk in association with reference.

Question 2. Triglyceride measurements in chronic heart disease (CHD) and its association with other disease states particularly pancreatitis.

Question 3. Influence of sex, age, exercise, obesity, alcohol and extraneous oestrogens on lipoproteins.

Question 4. Causes of secondary hyperlipidaemia.

Question 5. Causes of primary hyperlipidaemia and treatment (NICE guidelines).

Question 6. Principles and limitations of the analytical methods employed and sample requirements for: • cholesterol • triglyceride • HDL-cholesterol

Question 7. Factors affecting sample integrity and appropriate corrective action.

Question 8. How to calculate LDL-cholesterol, and non-HDL cholesterol and recognise its limitations.

Question 9. Other proposed markers of CHD